I doubt it. Even with new bladders (IF the old ones won’t work), fuel lines, possibly injectors, etc., especially if the FAA paves the approval path for such things. The engine proper will need nothing, and will likely now last longer.
Still, a fuel that doesn’t require mods would be better, but I’m old enough to remember when the vast majority of airports had two grades of piston fuel. Heck, many airports have two or three tankers, and some have split tankers. Or just have a “lead blender” to mix with the other stuff, for planes that must have it, until a solution (that doesn’t involve the demise of GA high-performance piston engines) is reached.