Airbus posed this a few years ago, but for freighters. But we can be sure that they would want to extend it to two pilot operations and make them single pilot.
Safety is the issue. All pilots make occasional mistakes and the second pilot is there to catch it. Equipment failures occur and it takes two to sort it out …
I started jet flying in a Citation 500 single pilot and I was buzzed with the speed - but it really takes two because things happen very fast.